|Title||STUDIES ON BIOLOGICAL ACTIVITIES OF BIO-NORMALIZER|
|Author||Hiromichi Okuda, Hiroji Ominami, Anqiang Zhou, Yukinaga Matsuura, James Akira Osato and Librado A. Santiago|
STUDIES ON BIOLOGICAL ACTIVITIES OF BIO-NORMALIZER
Hiromichi Okuda, Hiroji Ominami, Anqiang Zhou, Yukinaga Matsuura, James Akira Osato* and Librado A. Santiago**
2nd Department of Medical Biochemistry, School of Medicine, Ehime University
*Sun-0 International, Inc., **Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical School
The Clinical Report, 1993, 27: 47-56
Liver is the major organ of lipid metabolism. The metabolic by-product lipid peroxide induces hypercholesterolemia, hyperlipidemia, hypertension, myocardial infarction, diabetes, liver diseases and other geriatric diseases. In vivo study in rats demonstrated that oral administration of corn oil containing peroxides causes hyperlipidemia and liver injury in these laboratory animals. The effect of Bio-normalizer (BN) on hyperlipidemia and liver injury was examined. Oral administration of BN failed to affect cholesterol and triglyceride contents in the liver, but was able to inhibit lipid peroxidation in liver and serum. Increased levels of serum transaminases (GOT and GPT) induced by oral administration of corn oil were also decreased by BN. These findings suggest that BN can help prevent liver diseases caused by lipid peroxidation.