| Title | Effects of Dietary Supplement on Interferon-Producing Capacity in Humans |
|---|---|
| Year | A.Kishi, K.Uno, Y. Matsubara,J.A Osato, T.Kishida |
| Author | 1994 |
| Publisher | 1994 Annual Meeting on the ISICR |
Effects of dietary supplements on IFN producing capacity in humans
Atsuko KISHI, Kazuo UNO, Yuldo MATUSBARA, Akira OSATO and Tsunataro KISHIDA
Journal of Interferon Research 14.s 1: s179, 1994
(Presented at the ISICR ’94 Annual Meeting of Interferon System, Budapest, Hungary. October 2-7, 1994)
Interferons are substances produced by immune cells as a normal defense reaction to fight, mainly against virus infections. The interferon-producing capacity of blood cells is considered to be a useful parameter in evaluating immunological functions. Since Bio-Normalizer has been documented to possess immunomodulating activity, its effect on the interferon-producing capacity of human whole blood was investigated in this experiment. Bio-Normalizer was able to enhance the production of interferon
This finding suggests that Bio-Normalizer, being an enhancer of interferon production, can help improve the general condition and the quality of life of patients with impaired immune competence without any side effects.
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The JOURNAL OF INTERFERON RESEARCH publishes original papers in the field of interferon research. As indicated by the broad scope of interests represented by the editorial board, the JOURNAL OF INTERFERON RESEARCH will consider papers covering all aspects of interferon research ranging from the molecular biology of interferons and the interferon system to its use in-the clinic.
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PWll-8
THE TIME OF CD4+ T CELLS-DEPENDENT PROTECTION IN MICE INFECTED WITH TAENIA TAENIAEFORMIS (CESTODA)
K. Ishiwata, M. Asano, M. Kohanawa, T. Minagawa, Y. Sato, M. Kamiya, A. Nakane
Department of Microbiology, School of Medicine; Department of Parasitology,
Faculty of Veterinary Medicine, Hokkaido University, Sapporo Japan; Department of Microbiology, School of Medicine, Hirosaki University, Hirosaki, Japan
PW11-9
EFFECTS OF DIETARY SUPPLEMENTS
ON IFN PRODUCING CAPACITY IN HUMANS
A Kishi. K. Uno, Y. Matsubara, A. Osato, T. Kishida
Institut Pasteur de Kyoto, Kyoto, Japan ·
PW11-10
AGE-RELATED CHANGES IN NKC, ADCC AND INTERFERONS
K. Chadha, I. Stadler, M.P.N. Nair, D. Feinblatt
Roswell Park Cancer Institute, Buffalo General Hospital, Buffalo, NY, USA
PW11-11
PROTEIN KINASE C IN INTERFERON-GAMMA SIGNAL TRANSDUCTION
V. Aas, P. Toijesen, J.G. Iversen, H.B. Bemestad
Institute of Basic Medical Science, Department of Physiology, University of Oslo,
Oslo, Norway; Hormone Laboratory, Aker Hospital, Oslo, Norway
PW11-12
CONCERTED ACTION ON THE ANTIGENICITY OF RECOMBINANT DNA
DERIVED PHARMACEUTICALS
H. Schellekens, .P. Von Wussow
Delft, The Netherlands; Hanover, Germany
PW11-13
CD3+ /TCR-GAMMA-DELTA+ CELLS AND IFN-GAMMA PRODUCING CELLS
EXIST RESIDENTLY IN CNS TISSUE
K. Masashi. A. Misako, I. Kenji, M. Tomonori
Department of Microbiology, Hokkaido University School of Medicine, Sapporo,
Japan
PW11-14
PRODUCTION AND ACTION OF IL-10 IN PITUITARY CELLS
P.L. Rady, P. Cadet, S.K. Tyring, E.M. Smith, T.K. Hughes
Departments of Microbiology and Immunology, and Psychiatry and Behavioral
Sciences, The University of Texas Medical Branch, Galveston, TX. USA
PW11-15
EFFECTS OF LHRH AND TRH ON INTERFERON GAMMA PRODUCTION IN
VIVO AND IN VITRO
M. Muscettola, V. De Leo, G. Grasso
Institutes of General Physiology, Obstetrics and Gynecology, and Human
Anatomy, Siena, Italy
PW11-16
IMPAIRED PHAGOCYTOSIS AND PROMOTED BACTERIAL GROWTH
TRANSFERRED BY MEDIATORS OF LYMPHOCYTES INFECTED BY ADENO-VIRUSES AND HSV-1
J. Ongrádi, J. Farkas, K. Sallay, G. Varnai, G. Kulcsar, I. Nasz
Institute of Microbiology and Clinical Oral Surgery, Semmelweis University of
Medicine, Dental Surgery, Municipal Police Headquarters, Budapest, Hungary
S33
PWII-9
EFFECTS OF DIETARY SUPPLEMENTS ON IFN PRODUCING CAPACITY IN HUMANS
Atsuko KISHI, Kazuko UNO, Yuiko MATSUBARA,
Akira OSATO and Tsunataro KISHIDA
lnstitut Pasteur de Kyoto
We studied the effects of oral administration for one month of dietary supplements such as Labre, Bio-normalizer and Spirulina A on IFN producing capacity of the whole blood of human individuals. Labre is a newly isolated Lactobacillus brevis subsp. coagulans from suguki pickles. Bio-normalizer is a health food product of the fermentation of herbal plants. Spirulina A consists mainly of Spirulina alga. IFN-α producing capacity was determined by bioassay and IFN-γ producing capacity by time-resolved immunofluoroassay. The increased levels of IFN-α and IFN-γ production were observed in the Labre group and in the Bio-normalizer group, respectively, but no change of IFN production was seen in the Spirulina group. IFN- α and IFN- γ producing capacities are considered to be useful parameters of immunological functions. Therefore, it is suggested that the enhancement of these immunological functions improves the general condition and the quality of life of patients with impaired immune competence without any side effects.
PWll-10
AGE-RELATED CHANGES IN NKC, ADCC AND INTERFERONS.
K. Chadha, I. Stadler, M.P.N. Nair* and D. Feinblatt, Roswell Park. Cancer Inst.,
*Buffalo General Hospital, Buffalo, NY USA
The immune system and its microenvironment undergo complex changes during the aging process. In animal models, a decline in both humoral and cell mediated immunity has been documented with an increase in age. In humans, conflicting observations have been made with regard to cytotoxic potential of their lymphocytes (NKC, ADCC) during .aging. Variable results have also been reported with regard to IFN production and IFN-mediated mitogen and antigen responses. In our study, we have examined the effect of age and gender upon potential of peripheral blood lymphocytes for IFN production, NKC and ADCC activities. We have observed that both NKC and ADCC activities are higher in lymphocytes from older individuals (average age, 67 years) as compared ·to young adults (average age, 20 years). All participants in this study were free from alcohol and substance abuse habits. With regard to gender, no significant differences were seen in NKC activity but marginally significant differences were seen for ADCC. IFNα production by peripheral blood lymphocytes was significantly greater for younger than aged individuals.
Physiological significance of these observations will be discussed.
S179
ISICR ‘94 Annual Meeting or the International Society
for Interferon and Cytokine Research
October 2-7, 1994 · Hotel Marrion – Budapest, Hungary.
ABSTRACT FORM
EFFECTS OF DIETARY SUPPLEMENTS ON IFN PRODUCING CAPACITY IN HUMANS
Atsuko KISHI, Kazuko UNO, Yuiko MATSUBARA,
Akira OSATO and Tsunataro KISHIDA
lnstitut Pasteur de Kyoto
We studied the effects of oral administration for one month of dietary supplements such as Labre, Bio-normalizer and Spirulina A on IFN producing capacity of the whole blood of human individuals. Labre is a newly isolated Lactobacillus brevis subsp. coagulans from suguki pickles. Bio-normalizer is a health food product of the fermentation of herbal plants. Spirulina A consists mainly of Spirulina alga. IFN-α producing capacity was determined by bioassay and IFN-γ producing capacity by time-resolved immunofluoroassay. The increased levels of IFN-α and IFN-γ production were observed in the Labre group and in the Bio-normalizer group, respectively, but no change of IFN production was seen in the Spirulina group. IFN- α and IFN- γ producing capacities are considered to be useful parameters of immunological functions. Therefore, it is suggested that the enhancement of these immunological functions improves the general condition and the quality of life of patients with impaired immune competence without any side effects.
APPLICANT’S NAME: KISHI, ATSUKO
MAILING ADDRESS: Office
103-5, Mozen-cho, Tanaka, Sakyo-ku, Kyoto-city
Coutry: Japan Phone: 75-791-7726 Fax: 75-712-5850
PREFERENCE: □ Oral
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ISICR ’94 Annual Meeting of the International Society for Interferon and Cytokine Research
October 2-7, 1994 Hotel Marriot – Budapest, Hungary
EFFECTS OF DIETARY SUPPLEMENTS ON IFN PRODUCING CAPACITY IN HUMANS
Atsuko KISHI, Kazuo UNO, Yuldo MATUSBARA,
Akira OSATO and Tsunataro KISHIDA
Institut Pasteur de Kyoto
We studied the effects of oral administration for one month of dietary supplements such as Labre, Bio-normalizer and Spirulina A on IFN producing capacity of the whole blood of human individuals. Labre is a newly isolated Lactobacillus brevis subsp. coagulans from suguki pickles. Bio-normalizer is a health food product of the fermentation of herbal plants. Spirulina A consists mainly of Spirulina alga. IFN-α producing capacity was determined by bioassay and IFN-γ producing capacity by time-resolved immunofluoroassay. The increased levels of IFN-α and IFN-γ production were observed in the Labre group and in the Bio-normalizer group, respectively, but no change of IFN production was seen in the Spirulina group. IFN- α and IFN- γ producing capacities are considered to be useful parameters of immunological functions. Therefore, it is suggested that the enhancement of these immunological functions improves the general condition and the quality of life of patients with impaired immune competence without any side effects.